Posts

Showing posts with the label drug metabolism studies

Accelerating New Drug Development: The Role of Radioisotope Labeling

Image
  In drug development, Radioisotope labeling has become a powerful tool. It provides a means to track the fate of drugs in the body and helps researchers to better understand the metabolic processes and potential toxicity of new compounds. So, scientists can design more effective and safer drugs, reducing the risk of adverse effects and increasing the likelihood of success in clinical trials. Isotopes are atoms of the same chemical element with different masses due to the presence of different neutron numbers in the nucleus, and there are light and heavy isotopes; based on physical properties, isotopes can also be classified into two forms: radioactive and stable. Radioisotope labeling technology is a very useful tool in the process of new  drug development , and Medicilon offers radioisotope services. Based on physical properties, isotopes can be classified into two forms: radioactive and stable. Radioactive isotopes (e.g. 3H, 14C) undergo their decay process and radiate radi...

Pharmacological effects of selenium and its metabolism in rats

Image
 Organoselenium drugs are a new class of compounds. It has antiviral, antitumor, and neurological effects in pharmacological studies . Selenium has a variety of special functions for human health and is classified as one of the essential trace elements. Inorganic selenium compounds have high toxicity and relatively low lethal dose (LC50).  In contrast, organic selenium has high bioavailability, high bioactivity, low toxicity, and low environmental pollution. In vivo metabolism study of organic selenium in rats is conducted, which can provide a reference for the rational supplementation of organic selenium. Drug metabolism is one of the most critical factors affecting drug action, and in vivo drug metabolism studies have always been a focal issue in drug research. In vivo drug metabolism study refers to collecting biological samples such as blood, urine, and bile after administering drugs to animals or humans. Then after analysis and separation of drugs and drug metabolites in...