Medical News

 Systemic lupus erythematosus (SLE) is an autoimmune disease that produces large amounts of immune complexes and autoantibodies and causes damage to the kidneys, skin, joints, and central nervous system. Current SLE treatment is mostly glucocorticoid-led drug therapy, which has more toxic side effects. With the understanding of the pathogenesis of SLE, some targets for the treatment of SLE have emerged, and drugs developed with these targets have achieved some results in preclinical studies and clinical studies. In the future, the development of some biologically targeted therapeutic agents will have an important role in the treatment of SLE. 1. What is Systemic Lupus Erythematosus? SLE is a complex autoimmune disease that can affect multiple organs, including the skin, joints, heart, kidneys, and brain. Symptoms can vary widely and may include fatigue, joint pain, skin rashes, and fever. The course of the disease is unpredictable, with periods of remission and flares. 2. What Caus...

Understanding Preclinical Research: The Key to Successful Innovative Drug Development   The first challenge in drug development is preclinical research of new drugs, which refers to chemical synthesis or natural product purification studies, drug analysis studies, pharmacodynamics, pharmacokinetics, toxicology, and pharmacology studies performed before a drug enters clinical studies. Preclinical studies of new medicines escort the development of innovative drugs.  To New drug registration, it's vital to conduct preclinical research, including studies on the synthesis process, extraction method, physicochemical properties and purity, dosage form selection, prescription screening, preparation process, testing method, quality standard, stability, pharmacology, toxicology, animal pharmacokinetics, etc. Chinese medicine preparation also includes the original herbs' source, processing, and concoction. Biologics has quality standards, preservation conditions, genetic stability, an...