Exploring the Use of Humanized Mouse Models in Drug Safety Evaluation
The purpose of drug development is to find new safe, effective drugs of high quality and stability to cure diseases and save lives. Developing a new drug is a very complex process, but it can be divided into preclinical research and clinical studies of a new drug. Preclinical research is the first challenge in drug development , and preclinical toxicity studies of new medicines are an essential part of the journey from the laboratory to the clinic. Since many studies closely related to the safety of subjects, such as drug distribution, reproductive toxicity, and carcinogenicity studies, cannot be performed on issues in clinical trials, animal experiments have an irreplaceable role. However, there are differences between animals and humans, safety studies cannot be conducted on animal models alone, and normal animals do not respond to drugs the same way as patients. The humanized mouse model solves this challenge to some extent. Preclinical stu...