Medical News

 In innovative drug development, conducting toxicology studies to determine the type, dose, and mechanism of toxic response to a drug is essential to deciding on a drug's safety and efficacy, developing safe drug use strategies, and avoiding unnecessary drug toxicities. Generally, drug toxicology research includes the following : (1) Toxicity testing : drug toxicity tests are conducted in experimental animals or cells to assess the harmful effects of drugs on organisms. (2) Mechanism of toxicity studies : To understand the causes of toxic reactions by studying the mechanism of action of drugs. (3) Toxicity assessment: To assess drug safety and potential risks and develop reasonable drug use strategies. (4) Toxicological monitoring : to monitor the population using the drug and understand the long-term toxicity and adverse effects. In the early stage of R&D, the early combination of toxicological screening and evaluation can help improve the success rate of innovat...

 A growing number of studies have shown that dysbiosis of the intestinal flora is closely associated with the development of various diseases such as obesity, diabetes, non-alcoholic fatty liver, inflammatory bowel disease, and gastrointestinal tumors. Therefore, it is crucial to conduct intestinal flora metabolite analysis to explore the association between intestinal flora metabolite changes and host disease occurrence for disease prevention and treatment. Recently it has been shown that the composition of the gut microbiota in infancy, especially at two years of age, maybe the earliest warning sign for the detection of obesity. On the other hand, experiments conducted by some scientists in mice have found that the mammalian gut microbiome can be transmitted from generation to generation. With the development of microbial metabolomics, qualitative and quantitative methods can be used to understand the physiological status of microorganisms through the analysis of microbial metab...

  Starting from 2023, Medicilon will host a series of webinars with a wide range of critical topics in biotech industry, including IP strategies, licensing, M&A, investment, due diligence, finance, company management, the business environment between United States and China, as well as how Medicilon can support with its 20 years of establishment and new research and technology platforms. During the webinars, Medicilon will invite a group of senior industrial experts and executives in related fields to systematically introduce the ideas and key elements, share their experience, and conduct the in-depth discussions.  We sincerely invite you to join us!                                                     Agenda

 Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug! As an essential part of the development of the pharmaceutical industry, the chemical synthesis of drugs is the primary source of candidate drugs. It is also a high-input, high-output, and high-efficiency work. Medicilon is proud of our extensive expertise in synthetic organic chemistry, providing chemical synthesis services . Medicilon's synthetic chemistry team can independently design synthesis pathways and complex compound treatments, which is key to helping accelerate our clients' drug discovery. The research and development directions of chemically synthesized drugs mainly include the following: Research and development of new chemical entity drugs; Create "Me-too" new drugs—research and development of imitative new drugs; Further research and development of known drugs; Pharmaceutical research and development of existing drugs; Research on new uses of existing drugs...

 In the process of new drug development, it is necessary to conduct pharmacokinetic studies to analyze the pharmacokinetic parameters of drugs in vivo and use them as their outstanding advantages and effects.  Generally speaking, drugs with exceptional benefits should have shallow toxic side effects, good pharmacodynamic and pharmacokinetic properties, high efficiency of utilization and absorption, high solubility, and low toxicity of metabolites in vivo, etc., which can be used to guide new drug development and clinical drug use. The drug’s utilization and absorption efficiency are relatively high, and it has relatively high solubility. Moreover, the toxicity of metabolites in the body is relatively low, which can be used to guide the development of new drugs and clinical medication. Pharmacokinetics is a discipline that adopts mathematical principles and methods to quantitatively analyze and describe the dynamic processes of drugs and their regularity in vivo, which can qu...