Medical News

Understanding Preclinical Research: The Key to Successful Innovative Drug Development   The first challenge in drug development is preclinical research of new drugs, which refers to chemical synthesis or natural product purification studies, drug analysis studies, pharmacodynamics, pharmacokinetics, toxicology, and pharmacology studies performed before a drug enters clinical studies. Preclinical studies of new medicines escort the development of innovative drugs.  To New drug registration, it's vital to conduct preclinical research, including studies on the synthesis process, extraction method, physicochemical properties and purity, dosage form selection, prescription screening, preparation process, testing method, quality standard, stability, pharmacology, toxicology, animal pharmacokinetics, etc. Chinese medicine preparation also includes the original herbs' source, processing, and concoction. Biologics has quality standards, preservation conditions, genetic stability, an...

Long-term toxicity testing, also known as repeated dose toxicity tests, is a type of general toxicity tests and is an integral part and core component of non-clinical safety studies of drugs. General toxicity testing usually involves exposing test subjects to a chemical substance for a relatively short period (usually a few weeks or less) to determine the potential health effects of the essence after long-term exposure. In contrast, long-term toxicity testing involves exposing test subjects to a substance for a much more extended period, usually months or years, to determine the effects of long-term exposure. This type of testing is beneficial for assessing the chronic effects of a substance, such as the development of cancer or other chronic diseases. Therefore, long-term toxicity testing is one of preclinical toxicology studies ' most comprehensive, informative, and clinically relevant toxicological studies. Long-term toxicity testing is closely related to acute toxicity, reprod...