Medical News

 Natural products and their derivatives are essential for various drug lead compounds. Finding new drugs from active natural product skeletons and optimizing lead compounds is critical to drug development. Some chemical components of Chinese medicines are of great interest to pharmaceutical R&D workers because they may have multiple pharmacological activities .  Understanding the metabolism of natural products isolated from plants or synthesized using chemical methods in vivo can provide an individual material basis for pharmacodynamic and pharmacological studies of the drug. Rats or mice are usually used as animal models for the analysis of metabolites of compounds in vivo. Drug metabolism is one of the critical factors affecting the action of drugs. Studying the pathways and stability of drug metabolism, the enzymes and kinetic parameters involved in metabolism, and the drug interaction problems caused by metabolism are necessary to find efficient and less toxic drugs. T...

 A large number of candidate compounds is the basis for drug development, and compound activity screening and testing are critical to obtaining candidate compounds with clinical safety data. In screening candidate compounds, pharmacokinetic parameters are another important screening metric to examine potential compounds in addition to their efficacy, which can be used to better control drug development time and reduce drug development costs by excluding candidates with suboptimal pharmacokinetic parameters early in drug development. Image from pixabay Modern advances in science and technology have greatly accelerated the rate of drug candidate discovery, with thousands of new compounds requiring screening each year. When a candidate compound enters the clinical phase, it is usually studied in healthy volunteers to obtain the kinetic parameters of the drug in humans.  A large number of candidate compounds are often eliminated for pharmacokinetic reasons. Important pharmacokine...