Medical News

 Saponins are one of the main active ingredients of many herbal medicines such as ginseng, Polygala tenuifolia, Platycodon grandiflorum, licorice, rhizoma anemarrhenae, and radix bupleurum. Pharmacological studies have shown that saponins have biological activities such as antibacterial, antitumor, modulation of body metabolism and immunity, and treatment of cardiovascular diseases and diabetes mellitus. The in vivo metabolites of saponins were analyzed by chromatography-mass spectrometry to provide favorable evidence for the elucidation of the therapeutic mechanism of Chinese medicine. Liquid chromatography-mass spectrometry (LC/MS) is a bioanalytical technique that combines the high separation performance of high-performance liquid chromatography HPLC with the high sensitivity and specificity of tandem mass spectrometry. It does not require complete chromatographic separation between analytes, and its multi-window detection capability allows the quantitative analysis of multiple...

 A growing number of studies have shown that dysbiosis of the intestinal flora is closely associated with the development of various diseases such as obesity, diabetes, non-alcoholic fatty liver, inflammatory bowel disease, and gastrointestinal tumors. Therefore, it is crucial to conduct intestinal flora metabolite analysis to explore the association between intestinal flora metabolite changes and host disease occurrence for disease prevention and treatment. Recently it has been shown that the composition of the gut microbiota in infancy, especially at two years of age, maybe the earliest warning sign for the detection of obesity. On the other hand, experiments conducted by some scientists in mice have found that the mammalian gut microbiome can be transmitted from generation to generation. With the development of microbial metabolomics, qualitative and quantitative methods can be used to understand the physiological status of microorganisms through the analysis of microbial metab...

 The metabolite content of drugs in organisms is minimal, and it is not easy to isolate and prepare pure products. The metabolite structure is complex, and it is also challenging to obtain metabolites by chemical synthesis. Thus the study of metabolite analysis of drugs in organisms is minimal. Bitter ginseng is the dried root of bitter legume ginseng. The secondary metabolites currently isolated from bitter ginseng are mainly alkaloids and flavonoids, in addition to a few phenolic, triterpenoid, phenylpropanoid, fatty acid, and amino acid components. Domestic and foreign research focuses on its alkaloid components. The alkaloids extracted, isolated, and identified from the bitter ginseng plant now include bitter ginseng alkaloids, oxymatrine, iso-bitter ginseng alkaloids, hydroxy bitter ginseng alkaloids, lacustrine, oxymatrine, etc.  Metabolite identification refers to identifying and characterizing the small molecules (metabolites) present in a biological sample, such as b...

 Duhaldea cappa chrysanthemum belongs to traditional Chinese medicine in China. The study found that Duhaldea cappa chrysanthemum extract has an antibacterial effect on Staphylococcus aureus, a new antibacterial drug resource with potential for development.  The analysis of metabolites in the feces of rats after the administration of Duhaldea cappa extract is of great significance for the rational use of this herb and the development of new dosage forms. MetID plays a key role in drug discovery, preclinical development, and clinical development and is crucial for drug safety research and new drug development. Generally speaking, herbal medicines have antimicrobial activity due to various chemical components in the extracts. The analysis of metabolites of the active ingredients of herbal medications in animals and humans is essential for elucidating the effectiveness of herbal medicines, exploring the principles of action of the active ingredients, and explaining the rationali...