Medical News

In toxicology studies, there are two main types of tests used to assess the safety and potential toxic effects of drugs: in vivo tests and in vitro tests. We know that the traditional method of drug toxicology research is to use animal models for in vivo drug testing. Although this method can fully reflect the various toxic effects of drugs and allow long-term observation of chronic toxic effects, there are many interfering factors and it is difficult to conduct metabolic and mechanistic studies. With the development of science and technology, the use of free organs, cultured cells, or organelles for toxicological in vitro testing has slowly emerged. Toxicology is the science of studying the harmful effects of chemical, physical, biological, and other exogenous factors on biological systems. It can study the toxic reactions of chemical substances on living organisms, their severity, frequency of occurrence, and mechanisms of toxic effects, as well as qualitative and quantitative ev

 Systemic lupus erythematosus (SLE) is an autoimmune disease that produces large amounts of immune complexes and autoantibodies and causes damage to the kidneys, skin, joints, and central nervous system. Current SLE treatment is mostly glucocorticoid-led drug therapy, which has more toxic side effects. With the understanding of the pathogenesis of SLE, some targets for the treatment of SLE have emerged, and drugs developed with these targets have achieved some results in preclinical studies and clinical studies. In the future, the development of some biologically targeted therapeutic agents will have an important role in the treatment of SLE. 1. What is Systemic Lupus Erythematosus? SLE is a complex autoimmune disease that can affect multiple organs, including the skin, joints, heart, kidneys, and brain. Symptoms can vary widely and may include fatigue, joint pain, skin rashes, and fever. The course of the disease is unpredictable, with periods of remission and flares. 2. What Causes S