Medical News

 Organoselenium drugs are a new class of compounds. It has antiviral, antitumor, and neurological effects in pharmacological studies . Selenium has a variety of special functions for human health and is classified as one of the essential trace elements. Inorganic selenium compounds have high toxicity and relatively low lethal dose (LC50).  In contrast, organic selenium has high bioavailability, high bioactivity, low toxicity, and low environmental pollution. In vivo metabolism study of organic selenium in rats is conducted, which can provide a reference for the rational supplementation of organic selenium. Drug metabolism is one of the most critical factors affecting drug action, and in vivo drug metabolism studies have always been a focal issue in drug research. In vivo drug metabolism study refers to collecting biological samples such as blood, urine, and bile after administering drugs to animals or humans. Then after analysis and separation of drugs and drug metabolites in the mode

 Apigenin is a natural flavonoid widely found in plants and abundant in some fruits and vegetables. Metabolite Identification (MetID) plays a vital role in new drug development. In vivo drug metabolite analysis can provide a scientific basis for studying drug mechanisms of action and pharmacokinetics.  Biological samples were collected after administering apigenin to rats. Then Apigenin metabolites were analyzed by high-resolution mass spectrometry, which can clarify the possible metabolites and metabolic pathways of apigenin and provide a theoretical basis for the pharmacology of apigenin.  Many studies have shown that apigenin has significant antitumor activity, and apigenin has been found to modulate various molecular mechanisms related to cancer development in vitro and animal models. Some researchers used a nude mouse tumor model to evaluate the effect of apigenin against SGC-7901 human gastric cancer cells in vivo and found that apigenin inhibited gastric cancer cell proliferati

 Saponins are one of the main active ingredients of many herbal medicines such as ginseng, Polygala tenuifolia, Platycodon grandiflorum, licorice, rhizoma anemarrhenae, and radix bupleurum. Pharmacological studies have shown that saponins have biological activities such as antibacterial, antitumor, modulation of body metabolism and immunity, and treatment of cardiovascular diseases and diabetes mellitus. The in vivo metabolites of saponins were analyzed by chromatography-mass spectrometry to provide favorable evidence for the elucidation of the therapeutic mechanism of Chinese medicine. Liquid chromatography-mass spectrometry (LC/MS) is a bioanalytical technique that combines the high separation performance of high-performance liquid chromatography HPLC with the high sensitivity and specificity of tandem mass spectrometry. It does not require complete chromatographic separation between analytes, and its multi-window detection capability allows the quantitative analysis of multiple com

 A growing number of studies have shown that dysbiosis of the intestinal flora is closely associated with the development of various diseases such as obesity, diabetes, non-alcoholic fatty liver, inflammatory bowel disease, and gastrointestinal tumors. Therefore, it is crucial to conduct intestinal flora metabolite analysis to explore the association between intestinal flora metabolite changes and host disease occurrence for disease prevention and treatment. Recently it has been shown that the composition of the gut microbiota in infancy, especially at two years of age, maybe the earliest warning sign for the detection of obesity. On the other hand, experiments conducted by some scientists in mice have found that the mammalian gut microbiome can be transmitted from generation to generation. With the development of microbial metabolomics, qualitative and quantitative methods can be used to understand the physiological status of microorganisms through the analysis of microbial metabolit