Pharmacological effects of selenium and its metabolism in rats
Organoselenium drugs are a new class of compounds. It has antiviral, antitumor, and neurological effects in pharmacological studies . Selenium has a variety of special functions for human health and is classified as one of the essential trace elements. Inorganic selenium compounds have high toxicity and relatively low lethal dose (LC50). In contrast, organic selenium has high bioavailability, high bioactivity, low toxicity, and low environmental pollution. In vivo metabolism study of organic selenium in rats is conducted, which can provide a reference for the rational supplementation of organic selenium. Drug metabolism is one of the most critical factors affecting drug action, and in vivo drug metabolism studies have always been a focal issue in drug research. In vivo drug metabolism study refers to collecting biological samples such as blood, urine, and bile after administering drugs to animals or humans. Then after analysis and separation of drugs and drug metabolites in...