Medical News

 We all know that there are many causes of hair loss, but we never thought that the culprit of hair loss is intestinal flora. Scientists have pointed out that the analysis of the metabolites of the gut microflora is essential to understand how they affect human health, and that these metabolites can regulate the function of the immune system and the central nervous system. Metabolite analysis refers to the study of small molecules (metabolites) in biological systems, including cells, tissues, and organisms. It aims to identify, quantify, and understand the metabolic pathways, changes in metabolite levels, and relationships between metabolites and biological processes. Techniques used for metabolite analysis include NMR spectroscopy, mass spectrometry, and HPLC. The goal is to gain insights into biological function and identify markers for disease diagnosis and treatment. Gut microbes have a potential impact on human health, such as the corresponding changes in the gut microflora fo...

  Starting from 2023, Medicilon will host a series of webinars with a wide range of critical topics in biotech industry, including IP strategies, licensing, M&A, investment, due diligence, finance, company management, the business environment between United States and China, as well as how Medicilon can support with its 20 years of establishment and new research and technology platforms. During the webinars, Medicilon will invite a group of senior industrial experts and executives in related fields to systematically introduce the ideas and key elements, share their experience, and conduct the in-depth discussions.  We sincerely invite you to join us!                                                     Agenda

 The metabolite content of drugs in organisms is minimal, and it is not easy to isolate and prepare pure products. The metabolite structure is complex, and it is also challenging to obtain metabolites by chemical synthesis. Thus the study of metabolite analysis of drugs in organisms is minimal. Bitter ginseng is the dried root of bitter legume ginseng. The secondary metabolites currently isolated from bitter ginseng are mainly alkaloids and flavonoids, in addition to a few phenolic, triterpenoid, phenylpropanoid, fatty acid, and amino acid components. Domestic and foreign research focuses on its alkaloid components. The alkaloids extracted, isolated, and identified from the bitter ginseng plant now include bitter ginseng alkaloids, oxymatrine, iso-bitter ginseng alkaloids, hydroxy bitter ginseng alkaloids, lacustrine, oxymatrine, etc.  Metabolite identification refers to identifying and characterizing the small molecules (metabolites) present in a biological sample, such as b...

 Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug! As an essential part of the development of the pharmaceutical industry, the chemical synthesis of drugs is the primary source of candidate drugs. It is also a high-input, high-output, and high-efficiency work. Medicilon is proud of our extensive expertise in synthetic organic chemistry, providing chemical synthesis services . Medicilon's synthetic chemistry team can independently design synthesis pathways and complex compound treatments, which is key to helping accelerate our clients' drug discovery. The research and development directions of chemically synthesized drugs mainly include the following: Research and development of new chemical entity drugs; Create "Me-too" new drugs—research and development of imitative new drugs; Further research and development of known drugs; Pharmaceutical research and development of existing drugs; Research on new uses of existing drugs...

 In the process of new drug development, it is necessary to conduct pharmacokinetic studies to analyze the pharmacokinetic parameters of drugs in vivo and use them as their outstanding advantages and effects.  Generally speaking, drugs with exceptional benefits should have shallow toxic side effects, good pharmacodynamic and pharmacokinetic properties, high efficiency of utilization and absorption, high solubility, and low toxicity of metabolites in vivo, etc., which can be used to guide new drug development and clinical drug use. The drug’s utilization and absorption efficiency are relatively high, and it has relatively high solubility. Moreover, the toxicity of metabolites in the body is relatively low, which can be used to guide the development of new drugs and clinical medication. Pharmacokinetics is a discipline that adopts mathematical principles and methods to quantitatively analyze and describe the dynamic processes of drugs and their regularity in vivo, which can qu...

 Duhaldea cappa chrysanthemum belongs to traditional Chinese medicine in China. The study found that Duhaldea cappa chrysanthemum extract has an antibacterial effect on Staphylococcus aureus, a new antibacterial drug resource with potential for development.  The analysis of metabolites in the feces of rats after the administration of Duhaldea cappa extract is of great significance for the rational use of this herb and the development of new dosage forms. MetID plays a key role in drug discovery, preclinical development, and clinical development and is crucial for drug safety research and new drug development. Generally speaking, herbal medicines have antimicrobial activity due to various chemical components in the extracts. The analysis of metabolites of the active ingredients of herbal medications in animals and humans is essential for elucidating the effectiveness of herbal medicines, exploring the principles of action of the active ingredients, and explaining the rationali...